Barbital Sodium

Optimization of Barbital Sodium Content during Fermentation of Rifamycin B

利福霉素B发酵过程中巴比妥钠加量的优化

Conclusion It is a practical method to determine content of Barbital Sodium by PH Indicator Absorptance Method .

结论PH指示剂吸收度比值测定巴比妥钠的含量是一种切实可行的方法。

Objective To Study the better one between PH indicator absorptance method and Ag ration method to determine content of barbital sodium .

目的为探讨PH指示剂吸收度比值法和银量法测定巴比妥钠含量的优劣。

With barbital sodium sleep incubation period tests , we studied the effect of the capsules on the barbital sodium sleep incubation period .

通过巴比妥钠睡眠潜伏期实验，观察眠尔康胶囊对巴比妥钠睡眠潜伏期的影响。

Objective To observe the influence of the coumarins from Radix Angelicae pubescentis ( TCA ) on the hypnotic effects of pentobarbital sodium and barbital sodium .

目的观察独活香豆素组分（TCA）对戊巴比妥钠及巴比妥钠催眠作用的影响。

100 mg / kg of CAD was shown to significantly prolonged the latent period ( P < 0.01 ) and shortened the duration of hypnosis ( P < ( 0.01 )) induced by barbital sodium .

100mg/kgCAD组还可显著延长巴比妥钠催眠潜伏期（P<0.01），并缩短其睡眠时间（P<0.01）。

Conclusion The yield of rifamycin B is raised significantly with the technology optimized . The productivity of rifamycin B is increased by 17 % than that without barbital sodium and 10 % more than that produced at the present level .

结论优化工艺使发酵单位显著提高，比不加巴比妥钠提高17%，比目前生产水平提高10%以上。

Based on the Barbitone sodium hypnosis , the sample can shorten barbital sodium sleep-incubation-period of mouses , which explained there is the synergism between the Barbitone sodium and the samples ;

在巴比妥钠催眠的基础上，该受试物能缩短入睡时间，说明该受试物与巴比妥钠有协同作用；

Methods In shaken flask culture , the content and feeding strategy of barbital sodium during the fermentation of rifamycin B was optimized and the suitable fermentation technology was also defined by determining the potency of rifamycin B and PMV of mycelia in fermentation broth .

方法采用摇瓶发酵，优化巴比妥钠初始含量及中间补加策略，通过测定发酵液中利福霉素B的效价及菌体浓度来确定合适的发酵工艺。